Fellow blogger Erwin Kalvelagen posted a comparison of two binary programming models, one quadratically constrained and one linearly constrained, for the problem of selecting a maximal number of points from a finite set subject to the requirement that no two selected points be closer than a specified distance. The models were an answer to a question posted on Computational Science Stack Exchange. Not surprisingly, the linearized version tended to solve faster than the quadratic version.
In Erwin's linear model, the constraints take the form $$\underline{D}(x_i + x_j - 1) \le d_{i,j} \quad (1)$$ where $d_{i,j}$ is the distance between points $i$ and $j$, $\underline{D}$ is the minimum allowable distance between selected points, and $x_k$ is a binary variable indicating whether point $k$ is selected (1) or not (0). I coded both his models in Java, using CPLEX 22.1.1, along with another linear model where the constraints are expressed as $$x_i + x_j \le 1\quad (2)$$ for those pairs $(i,j)$ where $d_i + d_j \le \underline{D}.$ In other words, we exploit the fact that we know the distances at the outset to precompute which pairs of points can / cannot coexist, and just rule out the pairs that cannot. Since (1) is equivalent to $$x_i + x_j \le 1 + \frac{d_{i,j}}{\underline{D}},$$ constraint (2) is clearly at least a bit tighter than constraint (1).
Erwin started with a problem size of 50 points for demonstration purposes, then doubled that to compare timing of this two models. I ratcheted the problem size up to 1,000 points to compare his linear model to mine. (I did not test the quadratic model at that size.) As with all things MIP, the results were not entirely consistent. In limited testing, the model using (2) was usually faster than the model using (1), but occasionally (1) proved faster. The run time differences were not large enough to be exciting. For instance, in one test run version (1) needed 4.633 seconds versus 2.987 seconds for version (2).
Overall, I can't say the time differences lived up to my expectations, and the fact that at least occasionally (1) was faster than (2) (perhaps due to some quirk in presolving, or just to some random choices in branching) is consistent with my experience that MIP behaviors are, well, not consistent.